Dear Dr. Shirvani,
Thank you very much for taking time to send us your comments, we appreciate and welcome all comments and suggestions from our readers, specifically from medical and scientific community.
I am working in the field of HIV/AIDS since 9 years and am presently the scientific director at an AIDS organization in United State, performing pre-clinical and clinical trials on anti-HIV drugs, microbicide and HIV vaccine.
Indeed, it is possible that during translation the meaning of a word might change slightly. However we are concentrating lots of effort to minimize it, by explaining throughly the information and we also make sure that all information and statements posted on the website are accurate and based on the latest development in the field of HIV and AIDS.
We are all aware that the era of HIV/AIDS has changed. The antiretroviral therapy does not CURE the disease (darman nadarad) and as you rightly stated HIV has become a chronic disease like Diabetes in DEVELOPED countries. However, we would like to emphasize to our reader that even if they are under treatment, HIV virus is still present in their body and that they can TRANSMIT the virus to other people through well known routes of transmission (DARMAN gatii nadarad). I believe that the two word "aladj" and "darman" have similar meanings, but one is in Arabic and the second is in Farsi.
New vaginal microbicides are under investigation and some of them are in Phase I clinical trial. I think that you are talking about nanoxynol-9, which is indeed increases the risk of transmission through irritation and loss of vaginal epithelial cells. The Food and Drug Administration (FDA) has already issued several warnings about this compound and it is not used anymore as a vaginal microbicide. Lately the scientific and medical communities have concentrated lots of efforts to develop new version of vaginal and rectal microbicide that do not irritate vagina or rectum. This is mostly because women can use them without the consent of their partner (specifically in African countries) and also they are cost effective. Therefore such a compound can decrease the rate of transmission dramatically in developing countries. So the notion of microbicide being a "DOUBLE EDGE SWORDS" is not applicable for new version of these compounds.
Indeed, HIV vaccines are investigational and there is no efficient vaccine in the market against this disease, we never stated otherwise on our website.
Again thank you for your consideration and your helpful comments.
Marjan Hezareh, Ph.D.